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Systematic Reviews

A guide to creating a systematic review.

What Is a Systematic Review?

What Is a Systematic Review?

A systematic review aims to find all of the high-quality research on a particular topic, and make a summary of the evidence in that research. A systematic review is a type of literature review, but very thorough and structured.

Note that a systematic review is secondary research. This means that all of the information is found by reading journal articles (in some cases, perhaps other sources such as conference abstracts). The reviewers do not engage in any direct interactions with research participants/patients/subjects.

Overview of Steps

This list below makes it seem simple, but each of these steps will take significant time, especially the ones marked with an asterisk (*).

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A systematic review is a significant undertaking - a slow and methodical process. The resources in this guide are intended to assist you, but remember - there are no quick fixes! Although the amount of information may seem daunting, starting in the right way will save you time in the long run.

You may not need all of the information in this guide. It is intended to be comprehensive and provide options for many scenarios. Please use the navigation on the left to find the information that you need as you make your way through the systematic review process.

Don't forget to ask for help. Using the supports available to you will save you time and stress.

Systematic Review Comparisons

Main Types of Review Articles

Literature Review (aka Narrative Review)

A publication which summarizes information obtained from other sources (the other sources are usually research studies). Usually, the publication is a journal article, but sometimes it could be a book chapter, report, or even a webpage. Although there are best practices, there are no official guidelines nor rules. Best practices include thorough citation, citing mostly primary sources, performing a search of the literature to find relevant, high-quality sources, and maintaining an objective viewpoint (Hempel, 2019; Dawidowicz, 2010), but these are not always followed. Indeed, some advice on performing a literature review actually recommends citing secondary sources for efficiency (Hempel, 2019, p. 50). Often, the author's purpose is to save the reader's time by summarizing multiple sources, but critical analysis may also be offered. The structure of a literature review usually starts with an Introductions, and ends with Conclusions and a Reference List, but what appears in between can vary.

Systematic Review

A type of literature review which is exceptionally structured and comprehensive. The emphasis is on finding ALL of the available evidence on a topic, and making a summary. However, many systematic reviews limit to only higher-quality evidence. Several guidelines exist for performing a systematic review, and the reviewers usually pick at least one of these to follow. The protocol (methods) for the systematic review are decided before the review begins, and are not changed once the review begins. This includes an in-depth search strategy, attempting to find all relevant evidence, a screening process involving at least 3 experts, and a thorough evaluation of the quality of the resulting evidence. The structure of a systematic review usually includes the following sections: Abstract/summary, Introduction, Methods, Results, Discussion, Conclusions, and Reference List. Longer systematic reviews may also provide an Executive Summary, and some may provide a Plain Language Summary as well.

ASP project icon Note: the ASP project follows some but not all of the guidelines for a systematic review. The tab to the right, ASP vs syst review, gives a comparison of some of the major differences.

Other Types of Literature Reviews and Systematic Reviews

A type of systematic review which, in addition to providing an evidence-based summary of a topic, performs a statistical analysis of the data in those studies, and provides additional conclusions. Collecting data from multiple studies allows stronger statements due to the larger sample size, however, the analysis must take into account heterogeneity (differences) in the study protocols and populations. For instance, if a study of 100 people ages 14-25 and a study of 200 people ages 18-45 were analyzed together, the researchers would need to evaluate whether these age differences had any effect on the data. Note: a meta-analysis involves a statistical analysis of data, not to be confused with a pooled analysis where the data is collected together but not statistically analyzed.
An analysis of a small number of research studies where the data from the studies is simply collected together. This is only possible if the research protocols and study populations are similar, which is why there are usually only a small number of studies included (Blettner, 1999).
A type of systematic review where there are no limits placed on the type of evidence or information which can be included. All levels of evidence are included, as well as expert opinion, summaries, etc... Usually, the purpose of a scoping review is to determine the extent of information currently available on a topic - to determine how much literature already exists and what it covers, to identify any gaps, or to assess whether there is enough evidence available for a systematic review (University of Toronto Libraries, 2025). However, if enough information is found, a scoping review may present results and conclusions on the topic itself.
A systematic review of systematic reviews (University of Toronto Libraries, 2025). In this case, the reviewers would follow all of the normal steps for a systematic review, but they would select only systematic reviews and/or meta-analyses rather than selecting primary research articles. This would only be feasible for well-researched topics where multiple systematic reviews are available. This might be done to provide a concise evidence-based summary, or to analyze discrepancies between existing systematic reviews.
A review which collects both empirical (research-based) evidence and theoretical analyses. It may include both experimental and non-experimental data. This type of review acknowledges the value of evidence beyond the types traditionally included in a systematic review (University of Toronto, 2025).

 

Additional Definitions

A group of experts who are consulted before doing primary research, especially if living beings will be involved. The experts read the proposed research method or protocol, and look for ethical concerns. They may make suggestions or flag areas of concern. Consultation with a research ethics board is very important even if it seems that the research will be harmless - in fact, perhaps most important in such a case, if there is something to consider which might not be obvious.
Any research where the researchers collect data directly from the world itself, not the literature. They might collect data from research participants (for instance, they might perform interviews or focus groups to ask questions, or they might do an experiment), or in some cases, they could use a database which has been collecting information from individuals (e.g. a health insurance database containing information on medications prescribed and dispensed to patients). A primary source is a journal article (or other publication), which reports the results of this research.
Any research where the researchers collect data only from literature sources, usually journal articles, but perhaps also books, conference proceedings, etc... The researchers do not interact directly with any research participants. A secondary source is a journal article, book, or other publication) which reports a summary of the information found.

What Is the Difference Between a Literature Review and a Systematic Review?

The overall difference between a literature review and a systematic review is thoroughness. To create a literature review, you find some articles on a topic and summarize them. To create a systematic review, you find all the articles on a topic that you possibly can, evaluate them for quality, and summarize them.

Literature Review vs Systematic Review

 

Literature review / Narrative review

Systematic review

Overview

Collects and summarizes research on a topic.

Collects and summarizes research on a topic. Emphasis is on finding ALL available information, but there may be a focus on high quality evidence (Lefebvre et al, 2025).

Team

A single person or a team may do the work.

Generally, at least two people are involved in a systematic review (Lefebvre et al, 2025). Most guidelines recommend at least 2 subject experts for the screening process. Other team members can include an information specialist (librarian), statistician, and administrative assistants. Some teams recruit additional subject experts for publications needing translation.

Search strategy reporting

The authors may chose to include a methods section, indicating how they found the included research, or they may omit this information (Hempel, 2019, p. 119-120).

Provides detailed information about the search strategy, including the sources searched (databases, search engines, registers), date(s) on which they were searched, search strategies used, number of results found, and any additional methods used such as hand-searching, mining reference lists, citation tracking, etc... (Lefebvre et al, 2025, Page et al, 2021). Information provided should be sufficient to allow reproduction of the exact search.

Inclusion / exclusion criteria

The authors may or may not use inclusion and exclusion criteria.

Inclusion and exclusion criteria are clearly stated, and acceptable levels of evidence are usually defined before the search is undertaken (Lefebvre et al, 2025, Page et al, 2021). The emphasis is on what's appropriate for the subject matter - for instance, topics involving an intervention would likely focus on randomized controlled trials, while a discussion of prognostic factors would be more likely to accept cohort studies (OCEBM Levels of Evidence Working Group, 2011). Time period is usually all time, unless there is a logical start time, such as when a particular intervention was invented/discovered (Lefebvre et al, 2025).

Protocol

Reviewers usually simply begin work on the review - they do not publish a protocol.

Before the search begins, the reviewers decide upon a protocol for the review, which is often published ahead of time (Page et al, 2021). The reviewers adhere strictly to this protocol to prevent bias (Thomas et al, 2023). In some cases, small departures from the protocol may occur if justifiable (Thomas et al, 2023) - for instance, if the reviewers suddenly gain or lose access to a database. 

Guidelines

As of June 2025, there are no official guidelines for writing literature or narrative reviews (Equator Network, n.d.).

Although various sources, such as book and articles, give advice on writing a literature review (Hempel, 2019; Dawidowicz, 2010), authors may or may not consult these sources before working on their review. When it comes time to publish, the author(s) would likely consult guidelines for authors available on the website of the journal where they plan to submit the article.

The reviewers likely select and follow at least one of the guidelines for performing a systematic review.

Source (article) collection and screening

Some of the available advice on writing a literature review gives suggestions on how to make this process easier, but there are no requirements (Hempel, 2019).

Every search result from each of the databases is collected and stored. Duplicates are evaluated, counted, and removed. Each of the remaining citations is screened by two subject experts. A list of reasons for exclusion is drawn up, with each excluded article being tallied/recorded as it is removed. (Lefebvre et al, 2025).

Article retrieval

Sources which are not readily available may or may not be sought. Some advice on writing a literature review actually supports limiting to readily available sources, while acknowledging that relevant information may be lost (Hempel, 2019, p. 56).

Every citation which survives the initial screening process is sought (i.e. they try to find the entire article). Often a budget has been set aside for purchasing articles which are not readily available. Final screening decisions are made after the subject experts have reviewed the entire article.

Emphasis on primary research

Some advice on writing a literature review recommends using secondary sources, if the topic is well-researched, for efficiency (Hempel, 2019, p. 50). However, scholars are taught to cite primary sources whenever possible, to avoid misinterpretation errors (American Psychological Association, 2022), and most reviewers follow this advice.

The systematic review itself includes only primary sources, except in some cases meta-analyses may be included. 

The reviewers may use previously published systematic and literature reviews to identify primary research studies which were not found by their own search - they then locate, analyze, and cite the primary sources for their own systematic review (Lefebvre et al, 2025). The reviewers may also cite secondary sources in the Introduction or Discussion sections of their review, as background or for comparison.

Critical appraisal and bias analysis

The reviewer may or may not evaluate the quality of the sources they are including. If the reviewer notices a flaw or bias in a source, they may choose not to include it, or they may discuss it but point out the shortcomings. Various sources provide varying information about parameters to evaluate (Hempel, 2019, Chapters 4 and 7; Dawidowicz, 2010, Chapters 6 and 9).

The reviewers use rigorous methods to evaluate the quality of the studies (Page et al, 2021).

Note that finding methodological flaws or high risk of bias does not result in automatic exclusion from the review. In some cases, the effect of these flaws or bias on the study results may be thoughtfully explored and discussed (Higgins et al, 2019).

Presentation and citation of sources

The sources are indicated by in-text citations and a reference list. For the in-text citations, author-date style, endnotes, or footnotes may be used according to the chosen citation style.

Note: the absense of in-text citations does not necessarily disqualify a document from being a literature review - for instance, this is sometimes seen in older reviews. In a more recent document, absense of some kind of in-text citations should prompt suspicion - is this a non-scholarly source, or a predatory journal? However, this is still occasionally seen in literature reviews which either emphasize conciseness or a practical "how-to" focus.

In addition to in-text citations and a reference list, most systematic reviews contain tables presenting information about the included studies (Li et al, 2019). Common tables include:

  • Study characteristics

  • Study results

  • Study appraisals and/or risk of bias analyses

Topic permanence

The reviewer has likely picked a topic which they know has information available. If this turns out to be a mistake, they could adjust the topic.

Once the protocol has been established, the researchers do not make adjustments. A surprisingly large number of systematic reviews end with the statement that there wasn't any information of sufficient quality to be reviewed, and no conclusions can be drawn. 

Timing and follow-up searching.

The reviewer may be collecting additional sources as they write, or not. They may write the article within a short amount of time, e.g. a month, but if they take longer, they may or may not be watching for new articles, and so may or may not make updates just before submitting for publication.

Usually a significant amount of time passes between the day of database searching and the first draft of the article - the average is about a year. At that point, the subject experts ask the librarian to re-run the search and identify any new articles, at which time a mini-review (deduplication, screening, appraisal, and analysis) take place and the new information is incorporated into the article before publication (Lefebvre et al, 2025).

Iteration

There are no particular rules to whether a literature review is updated or stand-alone. This may be up to the reviewer, however, certain journals may encourage authors to write updates.

Systematic reviews may be done once or on a regular basis. Some systematic reviews are scheduled to be updated every 5 years. The reviewers generally keep all documentation between updates to streamline the updating process. The search strategies are generally reviewed before each update in case of new information, for instance if a new word/phrase has been coined, or a new treatment discovered.

Note: Information above which is not cited has come from personal experience - mostly from reading a lot of literature and systematic reviews, and participating in the searching parts of systematic reviews.

What Is the Difference Between the ASP Project and a Systematic Review?

There are several key differences between the parameters of the ASP project and a standard systematic review.

ASP vs Systematic Review

 

Systematic review

ASP

Overview

Collects and summarizes articles on a topic. Emphasis is on finding ALL available information.

Collects and analyzes articles on a topic. Emphasis is on recent articles of high relevance to the topic.

Team

Generally, at least two people are involved in a systematic review (Lefebvre et al, 2025).

A single person does the entire project. They are guided by their advisor, and can seek assistance from library staff, but all the work is their own.

Search strategy reporting

Provides detailed information about the search strategy, including the sources searched (databases, search engines, registers), date(s) on which they were searched, search strategies used, number of results found, and any additional methods used such as hand-searching, mining reference lists, citation tracking, etc...

As with a systematic review, provides detailed information about the search strategy, but within specific templates available on the DCP8806 course pages in Brightspace.

Inclusion / exclusion criteria

Inclusion and exclusion criteria are clearly stated, and acceptable levels of evidence are usually defined before the search is undertaken (Lefebvre et al, 2025, Page et al, 2021). The emphasis is on what's appropriate for the subject matter - for instance, topics involving an intervention would likely focus on randomized controlled trials, while a discussion of prognostic factors would be more likely to accept cohort studies (OCEBM Levels of Evidence Working Group, 2011). Time period is usually all time, unless there is a logical start time, such as when a particular intervention was invented/discovered (Lefebvre et al, 2025).

Some inclusion/exclusion criteria are defined by the project, such as peer reviewed, recent articles. Other inclusion/exclusion criteria are defined by the student (approved by the advisor). Unlike a standard systematic review, these may be adjusted at the time of searching or screening to obtain the correct number of articles as defined by the advisor (if approved by the advisor).

Protocol

Before the search begins, the reviewers decide upon a protocol for the review, which is often published ahead of time (Page et al, 2021). The reviewers adhere strictly to this protocol to prevent bias (Thomas et al, 2023). In some cases, small departures from the protocol may occur if justifiable (Thomas et al, 2023) - for instance, if the reviewers suddenly gain or lose access to a database.

In Unit 7, the student writes the Methodology section, which is the equivalent of the protocol. In most cases, for practical purposes, the student has already completed at least the search stage of their project, and adjustments may be made if approved by the advisor, for example, the student may limit to 5 years rather than 10 if there is a lot of research available.

Guidelines

The reviewers likely select and follow one of the guidelines for performing a systematic review.

The ASP project uses the PRISMA guidance, with some modification.

Source (article) collection

Every search result from each of the databases is collected and stored. Duplicates are evaluated, counted, and removed. Each of the remaining citations is screened by two subject experts. A list of reasons for exclusion is drawn up, with each excluded article being tallied/recorded as it is removed (Lefebvre et al, 2025).

Every search result from each of the databases is collected and stored. Duplicates are evaluated, counted, and removed. The student then screens the results, hopefully recording their decisions as they go along, using the PRISMA flow chart as a guide.

Article retrieval

Every citation which survives the initial screening process is sought (i.e. they try to find the entire article). Often a budget has been set aside for purchasing articles which are not readily available. Final screening decisions are made after the subject experts have reviewed the entire article.

The student may choose to focus on articles which are readily available, or may supplement by using the YU library's document delivery request form. 

Emphasis on primary research

The systematic review itself includes only primary sources, except in some cases meta-analyses may be included. 

The reviewers may use previously published systematic and literature reviews to identify primary research studies which were not found by their own search - they then locate, analyze, and cite the primary sources for the systematic review (Lefebvre et al, 2025). The reviewers may also cite secondary sources in the Introduction or Discussion sections of their review, as background or for comparison.

The systematic review itself includes only primary sources. Meta-analyses are not included in the articles to be analyzed. In some cases, the advisor may suggest including only qualitative or only quantitative studies.

As with a standard systematic review, other systematic reviews and meta-analyses may be used to identify interesting studies, or be cited in the introduction or discussion sections, as appropriate.

Critical appraisal and bias analysis

The reviewers use rigorous methods to evaluate the quality of the studies (Page et al, 2021).

Note that studies which are found to have methodological flaws or high risk of bias may not be excluded from the review, but rather, the effect of these flaws or bias on the study results may be thoughtfully explored and discussed (Higgins et al, 2019).

The reviews use critical appraisal tools identified by the advisor to evaluate the quality of the studies.

Presentation and citation of sources

In addition to in-text citations and a reference list, most systematic reviews contain tables presenting information about the included studies (Li et al, 2019). Common tables include:

  • Study characteristics

  • Study results

  • Study appraisals and/or risk of bias analyses

All documents are formatted according to APA 7th edition citation style, including in-text citations, references, and all other formatting.

The ASP templates indicate which information should be included in table form.

 

Guidelines

Guidelines for Systematic Reviews

Several organizations have created guidelines for doing systematic reviews.

The PRISMA guidance is widely used. Although this guidance may look daunting at first, the PRISMA statement can be used as a step-by-step guide to the systematic review procedure.

ASP project iconIf you are working on the ASP project for course DCP 8806, be sure to use the PRISMA guidance, as recommended in your course content. You do not have to type information into the PRISMA checklist, it is not a deliverable for your course. Just use it to make sure the right information is in your ASP reports. You will need to create a PRISMA flow diagramme for your report. (More about this in Step 7: Screening results.)

Other Available Guidelines

Certain journals have their own systematic review reporting standards. If you want to publish in a particular journal, it is recommended to check their author guidelines before proceeding.

The following tools were developed to help appraise systematic reviews, but the checklists can also be used as guides.

Document Everything!

Icon reminding you to document Document Everything!

A cardinal rule of doing a systematic review is to document everything that you are doing (Doyle-Waters, 2018).

Even if it seems trivial, even if you decide against using something after all, still keep a record of it. You never know when you'll need it again in future!

Things to record:

  • Reasons for early decisions, for instance, inclusion and exclusion criteria (see note below).
  • Narrower terms of subject headings used (this will be explained in Step 4: collecting terms).
  • Terms which were tested and not included in the search strategy.
  • The names and interfaces of the databases used (this will be explained in Step 5: selecting databases)
  • Exact search strategy used for each database, and number of results for each part of the search.
  • The date when each final database search was done.
  • The total number of results resulting from each database.
  • During the screening process, the number of results discarded for each reason (duplicate, irrelevant, wrong methodology, etc...).
  • It is highly recommended to retain a copy of each citation that's screened out as well as the ones which are kept at each stage.
  • Any notes and decisions made along the way.
  • The type of analysis selected and the guideline or framework used.
  • Any factors or decisions that affected the analysis.
  • Any tools or software used.

All of this information will be useful when you write your final report.

You may not expect it now, but it's possible that you may be called upon to update your systematic review in the future, and the more documentation you retain, the easier this is. Be kind to future you!

Note: you don't have to record reasons for really obvious decisions, for instance, if you limit to articles in the language(s) that you speak - you'll remember what language(s) you speak when it's time to write your report. Record any reasons which might not be obvious - for instance, suppose you were researching a technology, and found out that it became available to the public in 2017. You'd want to record where you found this information, so that you can cite it in your report, and how it impacted your inclusion criteria - perhaps you included articles published since 2015, to allow for anything published while the technology was being developed.

Record full citations for websites! If you find any information on a website which you might cite in your report, be sure to record the full citation of the website, not just the URL (link). Websites can sometimes disappear or change, and you'll need the full citation when it's time to write your report. If you don't want to spend a lot of time on this, the Zotero software can help.

References

References

American Psychological Association. (2022 July). Secondary sources. APA Style. https://apastyle.apa.org/style-grammar-guidelines/citations/secondary-sources

Blettner, M, Sauerbrei, W., Schlehofer, B., Scheuchenpflug, T., Friedenreich, C. (1999 Feb). Traditional reviews, meta-analyses, and pooled analyses in epidemiology. International Journal of Epidemiology, 28(1): 1-9. https://doi.org/10.1093/ije/28.1.1

Cochrane Collaboration. (n.d.). About Cochrane reviews. Cochrane Library. https://www.cochranelibrary.com/about/about-cochrane-reviews

Dawidowicz, P. (2010 October 1). Literature reviews made easy. Information Age Publishing. https://research.ebsco.com/linkprocessor/plink?id=eb1afff3-2c62-32f8-b279-ed6c82760a63

Equator Network. (n.d.). Enhancing the quality and transparency of health research. https://www.equator-network.org/

Hempel, S. (2019 September 10). Conducting your literature review. American Psychological Association. https://research.ebsco.com/linkprocessor/plink?id=f315f969-51cc-32c0-8940-40e29bbf8cfb

Higgins, J. P. T., Savović, J., Page, M. J., Elbers, R. G., Sterne, J. A. C. (2019 October). Chapter 8: Assessing risk of bias in a randomized trial. In: Higgins, J. P. T., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M. J., Welch, V. A. (Eds.),Cochrane Handbook for Systematic Reviews of Interventions. Cochrane. https://www.cochrane.org/authors/handbooks-and-manuals/handbook

OCEBM Levels of Evidence Working Group. (2011). The Oxford levels of evidence 2. Oxford Centre for Evidence-Based Medicine. https://www.cebm.ox.ac.uk/resources/levels-of-evidence/ocebm-levels-of-evidence

Lefebvre, C., Glanville, J., Briscoe, S., Featherstone, R., Littlewood, A., Metzendorf, M.-I., Noel-Storr, A., Paynter, R., Rader, T., Thomas, J., Wieland, L. S. (2025 March). Chapter 4: Searching for and selecting studies. In: Higgins, J. P. T., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M. J., Welch, V. A. (Eds.),Cochrane Handbook for Systematic Reviews of Interventions. Cochrane. https://www.cochrane.org/authors/handbooks-and-manuals/handbook

Li, T., Higgins, J. P. T., Deeks, J. J. (2019 October). Chapter 5: Collecting data. In: Higgins, J. P. T., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M. J., Welch, V. A. (Eds.),Cochrane Handbook for Systematic Reviews of Interventions. Cochrane. https://www.cochrane.org/authors/handbooks-and-manuals/handbook

Page, M. J., McKenzie, J. E., Bossuyt. P. M., Boutron. I., Hoffmann, T. C., Mulrow, C. D., et al. (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ, 372: n71. https://doi.org/10.1136/bmj.n71

Thomas, J., Kneale, D., McKenzie, J. E., Brennan, S. E., Bhaumik, S. (2023 August). Chapter 2: Determining the scope of the review and the questions it will address. In: Higgins, J. P. T., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M. J., Welch, V. A. (Eds.),Cochrane Handbook for Systematic Reviews of Interventions . Cochrane. https://www.cochrane.org/authors/handbooks-and-manuals/handbook

University of Toronto Libraries. (2025, April 28). Knowledge synthesis: systematic & scoping reviews, and other review types. https://guides.library.utoronto.ca/systematicreviews